STOMACH: HETEROTOPIC PANCREAS

COLON: MALAKOPLAKIA

ILEUM: VASCULITIS

STOMACH LOW GRADE DYSPLASIA

STOMACH LYMPHOCYTIC GASTRITIS

The red circles  point out  intraepithelial lymphocytes.

HISTOLOGICAL FINDINGS IN LYMPHOCYTIC GASTRITIS
1.-Lymphocytosis of foveolar and surface epithelium ,  greater than 25+ lymphocytes per 100 surface epithelial cells  
2.- chronic inflammation in lamina propria

ILEUM: CYTOMEGALOVIRUS ENTERITIS

The red square show intranuclear inclusions in CMV-infected cells , Owl´s eye intranuclear inclusions.

HISTOLOGY FINDINGS OF CYTOMEGALOVIRUS ENTERITIS
1.-Ulcers in ileum deep and well demarcate
2.-Intranuclear basophilic inclusions surrounded by clear halo in enlarged endothelium and stromal cells at ulcer base

STOMACH: GASTRIC LYMPHOMA

SESSILE SERRATED POLYP (AKA SESSILE SERRATED ADENOMA)

red square points out  basal dilation of the crypts, 

red square  basal dilation of the crypts, and crypts that run horizontal to the basement membrane (horizontal crypts.

red square show basal crypt serration and  crypt branching

HISTOLOGICAL FINDINGS OF  SESSILE SERRATED POLYP
1.-Serrated architecture with basal dilation of the crypts and basal crypt serration,  
2.- crypts that run horizontal to the basement membrane (horizontal crypts),
3.- crypt branching.
4.- Lack of nuclear dysplasia

COLON: INFLAMMATORY POLYP ( AKA PSEUDOPOLYP)

Left : red circle distorted crypt , Right : red arrow: granulation tissue

Sometimes, the inflammatory polyp consists only of granulation tissue, this is most common when the polyp is related to anatomosis

HISTOLOGICAL FINDINGS OF INFLAMMATORY POLYP
1.- Polyp composed of dilated, branched, and hyperplastic crypts with regenerative epithelium.
2.-Granulation tissue

Odze RD, Goldblum JR: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed. Elsevier: Philadelfia 2009
Greenson  Diagnostic Gastrointestinal and Liver Pathology ,Lippincott Williams &Wilkins, 2009.

COLON: HAMARTOMATOUS POLYP (INCLUDING PEUTZ JEGHERS POLYP)

Peutz Jegher polyp:Left picture shows polyp with papillary growth ; Right: red arrows indicates arborizing smooth muscle core

Sometimes, you can observed dystorted crypt, and hyperplastic change.

ANAL: CONDYLOMA ACUMINATUM

Black circles indicates binucleated cells, red arrow koilocytic cells.

Red arrow shows papillary fronds. Red circles: binucleated cells, green circle: koilocytic cells

HISTOLOGICAL FINDINGS OF CONDYLOMA ANAL
1.-Papillary  or exophytic growth pattern.
2.-Koilocytotic change: perinulcear halo surroun atypical nuclei.
3.-Binucleated cells.
4.-Parakeratosis

COLON: INFECTIOUS COLITIS (SELF LIMITED COLITIS)

Clasiccallly, no crypt disarray 

the circles indicate neutrophils inside crypts (cryptitis). In the right picture surface neutrophils with damage of epithelium 

No crypt distortion, the right picture indicates neutrophilic infiltration of crypts

The red square and circle  show microabscesses

Left. the red circle shows neutrophil, Right the red arrows indicates severe cryptitis

HISTOLOGICAL FINDINGS OF INFECTIOUS COLITIS:
1.-No crypt disarray or distortion.
2.- Neutrophilic infiltration in crypts (cryptitis) and surface epithelium, sometimes microabscess
3.-Damage of epithelium.

biblio:Odze RD, Goldblum JR: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed. Elsevier: Philadelfia 2009 and Greenson  Diagnostic Gastrointestinal and Liver Pathology ,Lippincott Williams &Wilkins, 2009.

COLON LIPOMA

The diagnosis is easy when you have the surgical specimen.

This was more difficult, but the endoscopy was more clear. The red square indicates submucosal fatty tissue

This is pseudolipomatosis (it is air  trapped in mucosa)  but  it can confuse  with lipoma

HISTOLOGICAL FINDINGS OF LIPOMA
1.- Rounded submucosal mass of mature adipose tissue

Odze RD, Goldblum JR: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed. Elsevier: Philadelfia 2009
Greenson  Diagnostic Gastrointestinal and Liver Pathology ,Lippincott Williams &Wilkins, 2009.

COLON: ULCERATIVE COLITIS

HISTOLOGICAL FINDINGS IN  ULCERATIVE COLITIS
1.- Crypt distortion: shortening and branching crypts., pseudovellous surface.
2.-Lymphoplasmocitosis basal.
3.- microabscess and cryptitis.

biblio:Odze RD, Goldblum JR: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed. Elsevier: Philadelfia 2009 and Greenson  Diagnostic Gastrointestinal and Liver Pathology ,Lippincott Williams &Wilkins, 2009.