COLON: LYMPHOCYTIC COLITIS

Red circles indicate intraepithelial lymphocytes; They are different to nucleus of epithelial cells, more rounded and darker. In this case , the count was 40 iel /100 epithelial cells.

Red circles indicate intraepithelial lymphocytes; They are different to nucleus of epithelial cells, more rounded and darker, besides the epithelial damage can be observed

Another case,a patient with chronic diarrhea,. Intraepithelial lymphocytosis  with  epithelial damage more evident

Sometimes, with immersion oil  100x, the difference between  epithelial nuclei and lymphocytes is more clear

HISTOLOGICAL FINDINGS IN LYMPHOCYTIC COLITIS
1.-Intraepithelial lymphocytosis , more than 20 iel/ 100 epithelial cells.
2.- Surface epithelial damage
3.- No crypt distortion.

biblio:Odze RD, Goldblum JR: Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd ed. Elsevier: Philadelfia 2009 and Greenson  Diagnostic Gastrointestinal and Liver Pathology ,Lippincott Williams &Wilkins, 2009.